Glenrock is located in central Wyoming at the foothills of the Rocky Mountains nestled along the confluence of the North Platte River and the Deer Creek Tributary System.

Glenrock, originally known as Deer Creek Station, had its beginning as a mail and stage station along the Oregon and Pony Express Trails.

The station served as a relay and eating place and was a vital supply point for thousands of emigrants as they traveled westward. Deer Creek flows into the North Platte River just to the north of town.